Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Dihydrocaffeic acid

Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[1078-61-1]

Product Name Alternative

3,4-Dihydroxy-benzenepropanoic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dihydrocaffeic-acid.html

Purity

99.65

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(O)CCC1=CC=C(O)C(O)=C1

Molecular Formula

C9H10O4

Molecular Weight

182.17

Precautions

H315, H319, H335

References & Citations

[1]Oliveira MM, et al. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxid Med Cell Longev. 2019 Jan 17;2019:2419096.|[2]Botta G, et al. Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses. Bioorg Med Chem. 2015 Sep 1;23 (17) :5345-51.|[3]Vázquez R, et al. Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. Bioorg Med Chem. 2012 Sep 15;20 (18) :5537-49. |[4]Huang J, et al. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. J Nutr Biochem. 2004 Dec;15 (12) :722-9. |[5]Lu R, et al. Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways. Bone Joint Res. 2023 Apr 6;12 (4) :259-273. |[6]Baeza G, et al. The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors. Food Funct. 2017 Mar 22;8 (3) :1333-1342.|[7]Lee K, et al. Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model. Molecules. 2015 Jun 30;20 (7) :11930-40.|[8]Poquet L, et al. Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells. Arch Biochem Biophys. 2008 Aug 15;476 (2) :196-204.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N2406/Dihydrocaffeic-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N2406/Dihydrocaffeic-acid-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; Microbial Metabolite; p38 MAPK

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GRPEL2 antibody
70R-2426 50 ug

GRPEL2 antibody

Ask
View Details
Recombinant ATP5F1D Antibody
RN-14793-01 50 μL

Recombinant ATP5F1D Antibody

Ask
View Details
Recombinant ATP5F1D Antibody
RN-14793-02 100 µL

Recombinant ATP5F1D Antibody

Ask
View Details
Recombinant ATP5F1D Antibody
RN-14793-03 1 mL

Recombinant ATP5F1D Antibody

Ask
View Details
TCR Alpha + TCR Beta Ab
MBS5317023-01 0.1 mg

TCR Alpha + TCR Beta Ab

Ask
View Details
TCR Alpha + TCR Beta Ab
MBS5317023-02 5x 0.1 mg

TCR Alpha + TCR Beta Ab

Ask
View Details