Fipamezole (hydrochloride)
Fipamezole hydrochloride is a potent and orally active α2-adrenergic receptor antagonist with Ki values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole hydrochloride is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease[1].
Product Specifications
CAS Number
150586-72-4
Product Name Alternative
MPV-1730 (hydrochloride) ; JP-1730 (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fipamezole-hydrochloride.html
Smiles
FC1=CC2=C(CC(C3=CN=CN3)(CC)C2)C=C1.Cl
Molecular Formula
C14H16ClFN2
Molecular Weight
266.74
References & Citations
[1]Juha-Matti Savola, et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord. 2003 Aug;18 (8) :872-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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