Human Thioredoxin Reductase 2

<strong>Human Thioredoxin Reductase 2</strong>_x000D_ <strong>Catalog number:</strong> B2016805_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> NADPH-dependent Thioredoxin Reductase 2, TrxR2, Txnrd2_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Park SJ, Kim HB, Piao C, Kang MY, Park SG, Kim SW, Lee JH. p53R2 regulates thioredoxin reductase activity through interaction with TrxR2 Biochem Biophys Res Commun. 2017 Jan 22;482(4):706-712._x000D_ 2: Nalvarte I, Damdimopoulos AE, Nystöm C, Nordman T, Miranda-Vizuete A, Olsson JM, Eriksson L, Björnstedt M, Arnér ES, Spyrou G. Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation J Biol Chem. 2004 Dec 24;279(52):54510-7._x000D_ 3: Kim JR, Lee SM, Cho SH, Kim JH, Kim BH, Kwon J, Choi CY, Kim YD, Lee SR. Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha FEBS Lett. 2004 Jun 4;567(2-3):189-96._x000D_ 4: Newick K, Cunniff B, Preston K, Held P, Arbiser J, Pass H, Mossman B, Shukla A, Heintz N. Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells PLoS One. 2012;7(6):e39404._x000D_ 5: Zhou J, Eleni C, Spyrou G, Brüne B. The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1alpha protein Free Radic Biol Med. 2008 Jan 1;44(1):91-8._x000D_ 6: Rackham O, Shearwood AM, Thyer R, McNamara E, Davies SM, Callus BA, Miranda-Vizuete A, Berners-Price SJ, Cheng Q, Arnér ES, Filipovska A. Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors Free Radic Biol Med. 2011 Mar 15;50(6):689-99._x000D_ 7: Xu Y, Fang F, Zhang J, Josson S, St Clair WH, St Clair DK. miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes PLoS One. 2010 Dec 22;5(12):e14356._x000D_ 8: Bu L, Li W, Ming Z, Shi J, Fang P, Yang S. Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity Life Sci. 2017 Jun 1;178:35-41._x000D_ 9: Patenaude A, Ven Murthy MR, Mirault ME. Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis J Biol Chem. 2004 Jun 25;279(26):27302-14._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/14695120">10: Rancourt RC, Tai S, King M, Heltshe SL, Penvari C, Accurso FJ, White CW. Thioredoxin liquefies and decreases the viscoelasticity of cystic fibrosis sputum Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L931-8. </a>_x000D_ _x000D_ <strong>Products Related to Human Thioredoxin Reductase 2 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>