Omidenepag isopropyl

Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isopropyl shows only weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as an intraocular pressure (IOP) -lowering agent.

Product Specifications

CAS Number

[1187451-19-9]

Product Name Alternative

DE-117

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/omidenepag-isopropyl.html

Purity

98.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OC(C)C)CNC1=NC(CN(CC2=CC=C(N3N=CC=C3)C=C2)S(=O)(C4=CC=CN=C4)=O)=CC=C1

Molecular Formula

C26H28N6O4S

Molecular Weight

520.60

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Kirihara T, et al. Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci. 2018 Jan 1;59 (1) :145-153.|[2]Fuwa M, et al. Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys. J Ocul Pharmacol Ther. 2018 Sep;34 (7) :531-537.