Steffimycin B

Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 μM, respectively) . It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC50=2.19 μM) .

Product Specifications

CAS Number

[54526-94-2]

Product Name Alternative

NSC 204855; U 40615

UNSPSC

12352005

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/steffimycin-b.html

Smiles

OC1=C(C(C2=C3O)=O)C(C(C2=CC(OC)=C3)=O)=CC(C4=O)=C1[C@H]([C@@H]([C@](O)4C)OC)O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5OC)O)OC

Molecular Formula

C29H32O13

Molecular Weight

588.56

References & Citations

[1]Trenado-Uribe, et al. Antimycobacterial activity of an anthracycline produced by an endophyte isolated from Amphipterygium adstringens. Mol. Biol. Rep. 45 (6), 2563-2570 (2018) .