5-Methoxyindole-3-acetic acid

5-Methoxyindole-3-acetic acid is a metabolite of Melatonin (HY-B0075) . 5-Methoxyindole-3-acetic acid significantly prolongs the estrous cycle, increases uterine weight, and induces ovarian follicular cysts in female rats, while also regulating the levels of related hormones[1][2][3].

Product Specifications

CAS Number

[3471-31-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/5-methoxyindole-3-acetic-acid.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CNC2=C1C=C(OC)C=C2

Molecular Formula

C11H11NO3

Molecular Weight

205.21

Precautions

H302, H315, H319, H335

References & Citations

[1]KVEDER S, et al. The metabolism of melatonin (N-acetyl-5-methoxytryptamine) and 5-methoxytryptamine. J Biol Chem. 1961 Dec;236:3214-20.|[2]Ocal-Irez T, et al. Effect of a pineal indolamine, 5-methoxyindole-3-acetic acid, on the estrous cycle and reproductive organs of female Wistar albino rats. Brain Res. 1989 Jul 24;493 (1) :1-7. |[3]Higa S, et al. Identification and quantification of 5-methoxyindole-3-acetic acid in human urine. Anal Biochem. 1985 Jan;144 (1) :86-93.