Acyclovir-d4
Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].
Product Specifications
CAS Number
[1185179-33-2]
Product Name Alternative
Aciclovir-d4; Acycloguanosine-d4
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Antibiotic; Apoptosis; Bacterial; HSV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Cancer; Infection
Purity
98.66
Solubility
10 mM in DMSO
Smiles
O=C1NC(N)=NC2=C1N=CN2COC([2H])([2H])C([2H])([2H])O
Molecular Formula
C8H7D4N5O3
Molecular Weight
229.23
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17422S1/Acyclovir-d4-SDS-MedChemExpress.pdf
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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