Zankiren
Zankiren (A-72517) is an orally active inhibitor for renin. Zankiren exhibits renal vasodilator effect, through reduction of angiotensin II formation without affecting other vasodilator mechanisms[1][2].
Product Specifications
CAS Number
138742-43-5
Product Name Alternative
A-72517
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zankiren.html
Smiles
O=C(N(NC(C(CS(=O)(N1CCN(C)CC1)=O)CC2=CC=CC=C2)=O)[C@@H](CC3CCCCC3)[C@@H](O)[C@@H](O)CC(C)C)CCC4=CSC=N4
Molecular Formula
C35H55N5O6S2
Molecular Weight
705.97
References & Citations
[1]Wessale JL, Kleinert HD, Calzadilla SV, Kovar PJ, Rosenberg SH.Effects of renin inhibitor A-72517 on hemodynamics and cardiac function in sodium-depleted dogs.Am J Hypertens. 1993 Jun;6 (6 Pt 1) :514-21.|[2]Fisher ND, et al., Renal vascular responses to renin inhibition with zankiren in men. Clin Pharmacol Ther. 1995 Mar;57 (3) :342-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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