RORγ/DHODH-IN-2
RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively[1].
Product Specifications
CAS Number
3000567-45-0
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; ROR; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
ClC1=C(C(F)=CC=C1)C2=NOC(C3=C(N(N=C3)C([2H])(CC(C)(C)O)[2H])C(F)(F)F)=C2C4=NC=CC=N4
Molecular Formula
C22H16D2ClF4N5O2
Molecular Weight
497.87
References & Citations
[1]Herrmann A, et al. Orally Bioavailable RORγ/DHODH Dual Host-Targeting Small Molecules with Broad-Spectrum Antiviral Activity[J]. Antiviral Research, 2024: 106008.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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