Licarin A
Product Specifications
UNSPSC Description
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].
Target Antigen
COX; Prostaglandin Receptor; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis;GPCR/G Protein;Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/licarin-a-1.html
Purity
98.48
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
OC1=CC=C([C@@H]2OC3=C(OC)C=C(/C=C/C)C=C3[C@H]2C)C=C1OC
Molecular Weight
326.39
References & Citations
[1]Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2252/Licarin-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2252/Licarin-A-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
51020-86-1
Available Sizes
Curated Selection
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