Goitrin

Goitrin ((S) -Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].

Product Specifications

CAS Number

[500-12-9]

Product Name Alternative

(S) -Goitrin; L-5-Vinyl-2-thiooxazolidone

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/goitrin.html

Purity

99.66

Solubility

10 mM in DMSO

Smiles

S=C1O[C@@H](C=C)CN1

Molecular Formula

C5H7NOS

Molecular Weight

129.18

Precautions

H302, H315, H319

References & Citations

[1]Felker P, et, al. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74 (4) :248-58.|[2]Wooding S, et, al. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem Senses. 2010 Oct;35 (8) :685-92.|[3]Nie LX, et, al. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J Ethnopharmacol. 2020 Apr 6;251:112550.