SMARCA2-IN-7
SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM[1].
Product Specifications
CAS Number
2270879-43-9
UNSPSC
12352005
Target
Epigenetic Reader Domain; SWI/SNF Complex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-in-7.html
Smiles
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
Molecular Formula
C11H9ClF2N4O2S
Molecular Weight
334.73
References & Citations
[1]Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM) /SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1) /SMARCA4-Mutant Cancers. Medicinal Chemistry. 2018 Nov 21;61 (22) :10155-10172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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