SMARCA2-IN-7

SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM[1].

Product Specifications

CAS Number

[2270879-43-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; SWI/SNF Complex

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smarca2-in-7.html

Smiles

O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO

Molecular Formula

C11H9ClF2N4O2S

Molecular Weight

334.73

References & Citations

[1]Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM) /SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1) /SMARCA4-Mutant Cancers. Medicinal Chemistry. 2018 Nov 21;61 (22) :10155-10172.