SMARCA2-IN-7
Product Specifications
UNSPSC Description
SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-in-7.html
Smiles
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
Molecular Weight
334.73
References & Citations
[1]Papillon JPN,et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Medicinal Chemistry. 2018 Nov 21;61(22):10155-10172.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161886/SMARCA2-IN-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161886/
Clinical Information
No Development Reported
CAS Number
2270879-43-9
Curated Selection
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