NF-κΒ activator 2
Product Specifications
UNSPSC Description
NF-κΒ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nf-κ-activator-2.html
Smiles
O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1
Molecular Weight
298.27
References & Citations
[1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134477/NF-κ-activator-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134477/NF-κ-activator-2-SDS-MedChemExpress.pdf
CAS Number
2375281-44-8
Available Sizes
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