NF-κΒ activator 2

NF-κΒ activator 2 is a potent and orally active NF- B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF- B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1].

Product Specifications

CAS Number

[2375281-44-8]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nf-κ-activator-2.html

Purity

99.76

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC(C2=CN=C(NC3=CC=CC=C3F)O2)=C1

Molecular Formula

C16H11FN2O3

Molecular Weight

298.27

Precautions

H315, H319

References & Citations

[1]Mathew B, et, al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.