NLRP3-IN-45
NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM) . NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-45.html
Smiles
O[C@@]12[C@@H](O)[C@]3([H])C(C)(C)CC=C[C@@]3(CO2)[C@@]4([H])[C@]1(C5=O)[C@H](OC(NC6=CC=C(F)C=C6)=O)[C@H](C5=C)CC4
Molecular Formula
C27H30FNO6
Molecular Weight
483.53
References & Citations
[1]Mengting Li, et al. Design, synthesis, and biological evaluation of oridonin derivatives as novel NLRP3 inflammasome inhibitors for the treatment of acute lung injury. Eur J Med Chem
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PDEH100593-01 20 µg
Recombinant Human CXCL4/CXCL4/PF4 Protein (Sumo Tag)
Sign In for Pricing
View Details PDEH100593-02 100 µg
Recombinant Human CXCL4/CXCL4/PF4 Protein (Sumo Tag)
Sign In for Pricing
View Details PDEH100593-03 500 µg
Recombinant Human CXCL4/CXCL4/PF4 Protein (Sumo Tag)
Sign In for Pricing
View Details PDEH100593-04 1 mg
Recombinant Human CXCL4/CXCL4/PF4 Protein (Sumo Tag)
Sign In for Pricing
View Details 
TRC-T350785-1MG 1 mg
6-Thioguanosine Triphosphate Triethylamine Salt (>90%)
Sign In for Pricing
View Details