Geldanamycin-FITC
Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm) [1][2][3].
Product Specifications
CAS Number
2969156-01-0
UNSPSC
12171500
Target
HSP
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/geldanamycin-fitc.html
Purity
98.43
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(NCCCCCCNC(NC1=CC=C(C(C(C=CC(O)=C2)=C2O3)=C4C3=CC(C=C4)=O)C(C(O)=O)=C1)=S)=C5C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C6C)C=C(NC(/C(C)=C/C=C\[C@H](OC)[C@H]\6OC(N)=O)=O)C5=O
Molecular Formula
C55H63N5O13S
Molecular Weight
1034.18
References & Citations
[1]Kim J, et al. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. J Biomol Screen. 2004;9 (5) :375‐381.|[2]Posfai D, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018;62 (4) :e01799-17. Published 2018 Mar 27.|[3]Imai T, et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011;108 (39) :16363‐16368.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
HSP90
Available Sizes
Frequently Asked Questions
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