Recombinant Human Platelet-derived growth factor subunit B protein (PDGFB) (Active)

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity) . {ECO:0000250}.

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb, c 3T3 cells is less than 3 ng, ml, corresponding to a specific activity of 3.3 105 IU, mg.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.