Zabofloxacin

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) [1].

Product Specifications

CAS Number

[219680-11-2]

Product Name Alternative

DW-224a (Free base)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Antibiotic; Bacterial; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/zabofloxacin.html

Purity

98.02

Solubility

10 mM in DMSO

Smiles

CO/N=C1C2(CNC2)CN(C3=C(F)C=C4C(N(C5CC5)C=C(C(O)=O)C4=O)=N3)C/1

Molecular Formula

C19H20FN5O4

Molecular Weight

401.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Park HS, et al. Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae. Molecules. 2016 Nov 17;21 (11) . pii: E1562.