DC432

HCT116 is a peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 of 54 nM. HCT116 can inhibit the N-terminal methylation level of NTMT1/2 substrates in HCT116 cells, and is used for the study of NTMT1/2 probes.

Product Specifications

CAS Number

[2388988-70-1]

UNSPSC

12352209

Target

Fluorescent Dye

Type

Peptides

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dc432.html

Solubility

10 mM in DMSO

Smiles

N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H]1N(CCC1)C(CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C55H100N28O10

Molecular Weight

1313.56

References & Citations

[1]Mackie BD, et al. Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 2020 Sep 10;63 (17) :9512-9522.