TAT-NEP1-40 (acetate)

TAT-NEP1-40 acetate is a therapeutic candidate for axonal regeneration and functional recovery after stroke. TAT-NEP1-40 acetate can protect PC12 cells against oxygen and glucose deprivation (OGD) and promote neurite outgrowth. TAT-NEP1-40 acetate protects the brain against ischemia/reperfusion injury through inhibition of neuronal apoptosis. TAT-NEP1-40 acetate can be efficiently delivered into the rat brains[1][2].

Product Specifications

UNSPSC

12352209

Target

Apoptosis

Type

Peptides

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tat-nep1-40-acetate.html

Purity

94.33

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CC(N)=O)=O)CO)=O)CC3=CC=C(O)C=C3)=O)CCCCN)=O)CCC(N)=O)=O)C(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CO)=O)[C@H](CC)C)=O)C)=O)C(C)C)=O)CCC(O)=O)=O)CO)=O)CCC(O)=O)=O)CC(C)C)=O)CC4=CC=C(O)C=C4)=O)C)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CCC2)=O)CC6=CNC=N6)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CO)=O)CCCCN)=O)CCC(N)=O)=O)[C@H](CC)C)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)C(C)C)=O)=O)CCCCN)=O)CC7=CC=C(O)C=C7)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O.O=C(O)C.[x]

Molecular Formula

C268H438N88O77.xC2H4O2

Molecular Weight

6124.89 (free base)

References & Citations

[1]Gou X, et al. TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke. J Drug Target. 2011 Feb;19 (2) :86-95.|[2]Wang Q, et al. Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis. Anesthesiology. 2008 Jun;108 (6) :1071-80.