Tanshinone IIA anhydride

Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with Ki values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively[1].

Product Specifications

CAS Number

[61077-78-9]

UNSPSC

12352005

Target

Carboxylesterase (CES)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tanshinone-iia-anhydride.html

Purity

97.03

Solubility

10 mM in DMSO

Smiles

CC1(CCCC2=C1C=CC3=C2C(OC(C4=C3OC=C4C)=O)=O)C

Molecular Formula

C19H18O4

Molecular Weight

310.34

References & Citations

[1]M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2018 Nov 26;81 (11) :2410-2418.|[2]M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2018 Nov 26;81 (11) :2410-2418.