Tanshinone IIA anhydride
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with Ki values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively[1].
Product Specifications
CAS Number
[61077-78-9]
UNSPSC
12352005
Target
Carboxylesterase (CES)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tanshinone-iia-anhydride.html
Purity
97.03
Solubility
10 mM in DMSO
Smiles
CC1(CCCC2=C1C=CC3=C2C(OC(C4=C3OC=C4C)=O)=O)C
Molecular Formula
C19H18O4
Molecular Weight
310.34
References & Citations
[1]M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2018 Nov 26;81 (11) :2410-2418.|[2]M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2018 Nov 26;81 (11) :2410-2418.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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