Anti-PSDR1 Antibody

Rabbit Polyclonal Antibody specific to PSDR1

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 1.1.1.300, Androgen-regulated short-chain dehydrogenase/reductase 1, HCV core-binding protein HCBP12, Prostate short-chain dehydrogenase/reductase 1, Retinal reductase 1, RalR1, Short chain dehydrogenase/reductase family 7C member 1

Gene Name

RDH11

NCBI Gene ID

UniProt

Q8TC12

Cellular Locus

Endoplasmic reticulum membrane, Single-pass type II membrane protein

Host

Rabbit

Reactivity

Human

Immunogen

N-terminal sequence MVELMFP and C-terminal sequence LLGLPID of human PSDR1.

Target Antigen

Retinol dehydrogenase 11

Target

PSDR1

Clonality

Polyclonal

Type

Antibody

Applications

WB, ELISA

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). {PubMed:12036956, PubMed:12226107, PubMed:15865448, PubMed:29410696}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution <br><br>ELISA: use at 1:1,000-1:5,000 dilution.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human PSDR1 (28 kD).

Formulation

PBS.

Target Background

Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate cancer. PSDR1 (prostate short-chain dehydrogenase- reductase 1) is a novel gene whose expression is increased following exposure of LNCaP cells to androgens. PSDR1 is highly expressed in the human prostate gland and is localized in both normal and neoplastic prostate epithelium. It has been suggested that PSDR1 may play a role in the pathogenesis of prostate cancer.