ALE-0540

ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain[1].

Product Specifications

CAS Number

[234779-34-1]

UNSPSC

12352005

Hazard Statement

H302+H312-H315-H318-H411

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ale-0540.html

Purity

98.24

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O

Molecular Formula

C14H11N3O5

Molecular Weight

301.25

Precautions

P264-P270-P273-P280-P302+P352-P305+P351+P338-P330-P362+P364-P391-P501

References & Citations

[1]Owolabi JB, et al. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1271-6.