(S) -GSK-F1

(S) -GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase α (PI4KIIIα) . (S) -GSK-F1 inhibits PI4Kα, PI4Kβ, PI4Kγ, PI3Kα, PI3Kβ and PI3Kδ with pIC50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S) -GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S) -GSK-F1 exhibits moderate pharmacokinetic characters in rat model[1].

Product Specifications

CAS Number

[1384097-27-1]

UNSPSC

12352005

Target

PI3K; PI4K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/s-gsk-f1.html

Purity

98.01

Smiles

O=C1C2=C(N=C(N1C3=CC=CC=C3C(F)(F)F)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2

Molecular Formula

C27H18F5N5O4S

Molecular Weight

603.52

References & Citations

[1]Leivers AL, et al., Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents. J Med Chem. 2014 Mar 13;57 (5) :2091-106.