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PROTAC PTK6 ligand-O-C2-O-piperidine-Boc

PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S, R, S) -AHPC and the corresponding Linker. (S, R, S) -AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-82.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)C)C2=CC(OCCOC3CCN(CC3)C(OC(C)(C)C)=O)=NO2)=O)NCC(C=C4)=CC=C4C(SC=N5)=C5C

Molecular Formula

C36H49N5O8S

Molecular Weight

711.87

References & Citations

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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