YX968

YX968 is a potent and selective HDAC3/8 PROTAC dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1]. (Pink: Target protein ligand (HY-168287) ; Black: linker (HY-W007700) ; Blue: E3 ligase ligand (HY-112078) )

Product Specifications

CAS Number

[2742732-92-7]

UNSPSC

12352005

Target

Apoptosis; HDAC; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yx968.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCNNC(C(C=C1)=CC=C1N(CC2)CCN2CCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)=O

Molecular Formula

C45H66N8O5S

Molecular Weight

831.12

References & Citations

[1]Xiao Y, et al. HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation. Cell Chem Biol. 2023 Nov 16;30 (11) :1421-1435.e12.