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KY 234

KY 234 is an orally effective inhibitor that targets thromboxane A2 production, with an IC50 of 5 μM. KY 234 significantly inhibits leukotriene D4 (LTD4), histamine, and antigen-induced bronchoconstriction in guinea pigs, with IC50 values of 6.0 mg/kg, 2.5 mg/kg, and 6.3 mg/kg, respectively[1].

Product Specifications

CAS Number

172544-75-1

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ky-234.html

Smiles

O=C(C1=CC2=C(C=C1)C(CN3C=CN=C3)=CN2CCCN4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)O[Na]

Molecular Formula

C33H34N5NaO2

Molecular Weight

555.65

References & Citations

[1]KAMIYA S, et al. Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives[J]. Chemical and pharmaceutical bulletin, 1995, 43 (10) : 1692-1695.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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