Puxitatug samrotecan drug-linker

Puxitatug samrotecan drug-linker (AZD8205 drug-linker) is a drug-linker conjugate for ADC, which comprises a topoisomerase I inhibitor and a linker. Puxitatug samrotecan drug-linker can be used to synthesis antibody-drug conjugate (ADC), Puxitatug samrotecan (HY-171689) [1].

Product Specifications

CAS Number

[3025787-81-6]

Product Name Alternative

AZD8205 drug-linker

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/puxitatug-samrotecan-drug-linker.html

Purity

98.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(C(CC6=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O

Molecular Formula

C60H84N8O20S

Molecular Weight

1269.42

References & Citations

[1]Conilh L, et al. Payload diversification: a key step in the development of antibody–drug conjugates[J]. Journal of Hematology & Oncology, 2023, 16 (1) : 3.