Rotundine
Product Specifications
UNSPSC Description
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.
Target Antigen
5-HT Receptor; Dopamine Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Rotundine.html
Purity
99.96
Solubility
DMF : 100 mg/mL (ultrasonic)|DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
Molecular Weight
355.43
References & Citations
[1]Wang JB, et al. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future Med Chem. 2012 Feb;4(2):177-86.|[2]Liu YL, et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol Sin. 2005 May;26(5):533-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0096/Rotundine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0096/Rotundine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
483-14-7
Available Sizes
Curated Selection
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