Tin (IV) mesoporphyrin IX (dichloride)

Tin (IV) mesoporphyrin IX dichloride (Stannsoporfin) is an orally active heme oxygenase (HO) inhibitor. Tin (IV) mesoporphyrin IX dichloride increases DENV RNA replication. Tin (IV) mesoporphyrin IX dichloride enhances the bactericidal activity of the SPaO regimen against chronic Mycobacterium tuberculosis (Mtb) -infected mice. Tin (IV) mesoporphyrin IX dichloride exhibits antitumor effects. Tin (IV) mesoporphyrin IX dichloride is being developed to prevent the development of jaundice in infants with hyperbilirubinemia[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[106344-20-1]

Product Name Alternative

Stannsoporfin; SnMP

UNSPSC

12352211

Target

Bacterial; Dengue Virus; Heme Oxygenase (HO)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tin-iv-mesoporphyrin-ix-dichloride.html

Purity

95.0

Solubility

DMSO : 5.56 mg/mL (ultrasonic)

Smiles

[Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(CC)=C6C)[N]1=C6C=C(C(CC)=C7C)[N-]2C7=CC8=[N]3C(C(CCC(O)=O)=C8C)=C5)[Cl-]

Molecular Formula

C34H36Cl2N4O4Sn

Molecular Weight

754.29

References & Citations

[1]Benjamin Levinson, et al. Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin. US20080113955A1.|[2]Lakhani HV, et al. Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction. J Clin Med Sci. 2024;8 (2) :1000275. Epub 2024 May 20.|[3]Hou C, et al. Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8+ T Cells and in Uveal Melanoma. Invest Ophthalmol Vis Sci. 2024 Aug 1;65 (10) :37. |[4]Sosnowska D, et al. Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation. JCI Insight. 2025 Jul 8;10 (16) :e191017. |[5]Ou YL, et al. Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. Int J Mol Sci. 2025 Jun 20;26 (13) :5921. |[6]Castillo JR, et al. The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model. bioRxiv [Preprint]. 2023 Nov 13:2023.08.09.552716. |[7]Williams M M, et al. 905 Metastatic triple-negative breast cancer secretes heme metabolites to alter macrophage immune suppression and function. 2024.