CPPG

CPPG ((RS) -CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

Product Specifications

CAS Number

[183364-82-1]

Product Name Alternative

(RS) -CPPG

UNSPSC

12352005

Hazard Statement

H302

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cppg.html

Purity

99.0

Smiles

O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2

Molecular Formula

C11H14NO5P

Molecular Weight

271.21

Precautions

H302

References & Citations

[1]Toms NJ, et al. The effects of (RS) -alpha-cyclopropyl-4-phosphonophenylglycine ((RS) -CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119 (5) :851-4.