SDH-IN-17
SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC50=0.170 μg/mL) . SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research[1].
Product Specifications
UNSPSC
12352005
Target
Fungal; Succinate Dehydrogenase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sdh-in-17.html
Smiles
O=C(NNC1=CC=C(Br)C=C1)COC2=C(C3=CC=CC=C3OC)OC4=C(C=CC=C4)C2=O
Molecular Formula
C24H19BrN2O5
Molecular Weight
495.32
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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