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N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].

Product Specifications

CAS Number

108212-76-6

Product Name Alternative

N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicin

UNSPSC

12352005

Hazard Statement

H300, H310, H315, H319, H330, H335, H351

Target

ADC Payload; Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/N-Acetyl-Calicheamicin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSSC

Molecular Formula

C57H76IN3O22S4

Molecular Weight

1410.39

Precautions

H300, H310, H315, H319, H330, H335, H351

References & Citations

[1]K C Nicolaou, et al. Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118 (25) :e2107042118.|[2]Breanna S Vollmar, et al. Calicheamicin Antibody-Drug Conjugates with Improved Properties. Mol Cancer Ther. 2021 Jun;20 (6) :1112-1120.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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