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Protoescigenin 21-tiglate

Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively[1].

Product Specifications

CAS Number

7047-43-0

Product Name Alternative

(E) -21-Angeloyl-protoaescigenin

UNSPSC

12352211

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

CANCER

Assay Protocol

https://www.medchemexpress.com/protoescigenin-21-tiglate.html

Smiles

OC[C@]12[C@](CC(C)([C@H]([C@@H]2O)OC(/C(C)=C/C)=O)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@](C)([C@H](CC4)O)CO)([H])CC5)C)([H])[C@]5(C)[C@@]3(C[C@H]1O)C

Molecular Formula

C35H56O7

Molecular Weight

588.81

References & Citations

[1]Yang Y, et al. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro[J]. RSC advances, 2019, 9 (54) : 31758-31772.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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