Pan-KRAS-IN-9
Pan-KRAS-IN-9 (Compound 52) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.24 and 0.30 nM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-9.html
Solubility
10 mM in DMSO
Smiles
CO[C@@H](C)C(N=C1)=[C@@]([C@@]2=C(CC(C)(C)COC3=O)C4=CC(C5=CSC(C[C@H](NC([C@H]6[C@H](C)[C@@H]6C)=O)C(N7CCC[C@@H]3N7)=O)=N5)=CC=C4N2CC)C=C1C#CCN8CCN(C)CC8
Molecular Formula
C48H62N8O5S
Molecular Weight
863.12
References & Citations
[1]Chen YF, et al., Pan-kras inhibitor compound. WO2024060966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15099938 1 Vial
Lentiviral human HADH shRNA (UAS) - Lentiviral human HADH shRNA (UAS, iRFP) (25)
Ask
View Details 
GTR15332116 1 Vial
Lentiviral human DAPL1 shRNA (UAS) - Lentiviral human DAPL1 shRNA (UAS, RFP) plasmid
Ask
View Details MBS9015792 Inquire
Rabbit anti-Oryza sativa subsp. japonica (Rice) CSTLP4 Polyclonal Antibody
Ask
View Details