2,4,5-Trimethoxybenzoic acid

2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a compound identified in purple perilla extracts. 2,4,5-Trimethoxybenzoic acid inhibits LPS (HY-D1056) -induced inflammatory responses, inhibits the activation of NF-κB and STAT signaling pathways. 2,4,5-Trimethoxybenzoic acid inhibits M1 macrophage phenotype-mediated inflammation in diabetes[1].

Product Specifications

CAS Number

[490-64-2]

Product Name Alternative

Asaronic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; STAT

Type

Natural Products

Related Pathways

JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-4-5-trimethoxybenzoic-acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(OC)=C(OC)C=C1OC

Molecular Formula

C10H12O5

Molecular Weight

212.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Oh H, et al. Asaronic Acid Attenuates Macrophage Activation toward M1 Phenotype through Inhibition of NF-κB Pathway and JAK-STAT Signaling in Glucose-Loaded Murine Macrophages. J Agric Food Chem. 2019;67 (36) :10069-10078.