BRL-44408 (maleate)

BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM) . BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP) -induced acute lung injury[1][2].

Product Specifications

CAS Number

[681806-46-2]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brl-44408-maleate.html

Purity

99.0

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

CC1N(CC2=NCCN2)CC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O

Molecular Formula

C17H21N3O4

Molecular Weight

331.37

References & Citations

[1]Dwyer JM, et al. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13 (9) :1193-205.|[2]Cong Z, et al. α2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway. J Cell Physiol. 2020 Oct;235 (10) :6905-6914.