BRL-44408 (maleate)
BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM) . BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP) -induced acute lung injury[1][2].
Product Specifications
CAS Number
681806-46-2
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/brl-44408-maleate.html
Purity
99.0
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
CC1N(CC2=NCCN2)CC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O
Molecular Formula
C17H21N3O4
Molecular Weight
331.37
References & Citations
[1]Dwyer JM, et al. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13 (9) :1193-205.|[2]Cong Z, et al. α2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway. J Cell Physiol. 2020 Oct;235 (10) :6905-6914.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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