Recombinant Murine Dendritic Cell Inflammatory Protein-1/CXCL3
Product Specifications
Background
CXCL3, also known as DCIP1 in murine, CINC2 in rat, and GROγ in humans, is belonging to the CXC chemokine family. It is encoded by the gene CXCL3 in mouse. The functional receptor for CXCL3 has been identified as CXCR2. Similar to other GRO proteins, CXCL3 is potent neutrophil attractants and activators. CXCL3 plays a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. The amino acid sequence of murine CXCL3 is 57 % identical to human CXCL3.
Gene ID
330122
UniProt
Q6W5C0
Target
AVVASELRCQ CLNTLPRVDF ETIQSLTVTP PGPHCTQTEV IATLKDGQEV CLNPQGPRLQ IIIKKILKSG KSS
Purification
> 97 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ugof rMuDCIP-1/CXCL3 as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of 10-100 ng/ml.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 7.9 kDa, a single, non-glycosylated polypeptide chain containing 73 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli
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