Anti-TIGIT [AET2010]

Product Specifications

Gene Name

[TIGIT]

NCBI Gene ID

201633

Reactivity

Human

Storage Conditions

Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

Specificity

This antibody binds the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Other Gene Names

[TIGIT; TIGIT; VSIG9; VSTM3; WUCAM; VSIG9; VSTM3]

Short Name

[TIGIT]

Other Product Names

[T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3]