Anti-TIGIT [4A5]
Product Specifications
Gene Name
[TIGIT]
NCBI Gene ID
201633
Reactivity
Human
Storage Conditions
Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
Specificity
This antibody binds the extracellular domain of the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Other Gene Names
[TIGIT; TIGIT; VSIG9; VSTM3; WUCAM; VSIG9; VSTM3]
Short Name
[TIGIT]
Other Product Names
[T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3]
NCBI GI Number
121943253
NCBI Accession Number
Q495A1.1
Uniprot Accession Number
Q495A1
Available Sizes
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