Anti-Aquaporin 4 [C9401]
Product Specifications
NCBI Gene ID
361
Reactivity
Human
Storage Conditions
Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
Specificity
This antibody recognizes and binds extracellular domains of both the M1 and M23 isoforms of human aquaporin 4 (AQP4), but not mouse aquaporin 4. AQP4 is a water channel expressed on astrocytes throughout the CNS and in skeletal muscle and some epithelial cells outside of the CNS. It plays an important role in brain water homeostasis and in glymphatic solute transport. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) that is associated with demyelination and neurological deficits in optic nerve, spinal cord and brainstem. Most NMOSD patients are seropositive for IgG autoantibodies (NMO-IgG) directed against extracellular epitopes of aquaporin-4 (AQP4). Prevention of the binding of NMO-IgG, therefore, may alleviate the disease.
Other Gene Names
[AQP4; AQP4; MIWC; HMIWC2; AQP-4; MIWC]
Short Name
[Aquaporin 4]
Other Product Names
[Aquaporin-4; Aquaporin-4; aquaporin-4; WCH4; aquaporin type4; aquaporin 4 isoform delta4; mercurial-insensitive water channel; aquaporin 4; Mercurial-insensitive water channel; MIWC; WCH4]
NCBI GI Number
2506859
NCBI Accession Number
P55087.2
Uniprot Accession Number
P55087
Available Sizes
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