Anti-BRAF V600E protein [600E-7]
Product Specifications
Gene Name
[BRAF]
NCBI Gene ID
673
Reactivity
Human
Storage Conditions
Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.
Specificity
This antibody is specific for the V600E mutation of the BRAF protein kinase. BRAF V600E mutation can promote the methylation of the thyrotropin receptor (TSHR) gene promoter, resulting in silencing of TSHR or a significant decrease in expression, and feedback increase of thyrotropin (TSH), which promotes the growth of tumor cells. BRAF V600E gene mutation and telomerase reverse transcriptase (TERT) promoter mutation also play an important role in the occurrence of papillary thyroid carcinoma (PTC).
Other Gene Names
[BRAF; BRAF; NS7; BRAF1; RAFB1; B-RAF1; BRAF1; RAFB1]
Short Name
[BRAF V600E protein]
Other Product Names
[serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase B-raf; serine/threonine-protein kinase B-raf; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p94); v-raf murine sarcoma viral oncogene homolog B1; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1]
NCBI GI Number
33188459
NCBI Accession Number
NP_004324.2
NCBI GB Accession Number
NM_004333.4
Uniprot Accession Number
P15056
Available Sizes
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