Anti-ABCG2 [5D3]

This antibody recognizes and binds a conformation-sensitive external epitope of ABCG2 on living cells. ABCG2 is a broad substrate specificity ATP-dependent transporter from the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. (PMID:11306452, 12958161, 19506252, 20705604, 28554189, 30405239, 31003562). The human ABCG2 protein is an important primary active transporter for hydrophobic compounds in several cell types, and its overexpression causes multidrug resistance in tumors (PMID: 15557326). ABCG2 is associated with drug resistance in acute myeloid leukemia (AML) (PMID: 12393637). ABCG2 expression may also have potential as a marker that identifies human limbal epithelial stem cells (PMID: 15625123).

[ATP-binding cassette sub-family G member 2; ATP-binding cassette sub-family G member 2; ATP-binding cassette sub-family G member 2; urate exporter; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter G2; mitoxantrone resistance-associated protein; placenta-specific ATP-binding ca; ATP-binding cassette, sub-family G (WHITE), member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter]