Human 5-Hydroxytryptamine 2C Receptor

<strong>Human 5-Hydroxytryptamine 2C Receptor</strong>_x000D_ <strong>Catalog number:</strong> B2016533_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> N/A_x000D_ <strong>Keywords:</strong> 5-HT-2C_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Monti JM. Serotonin control of sleep-wake behavior Sleep Med Rev. 2011 Aug;15(4):269-81._x000D_ 2: Przegaliński E, Witek K, Wydra K, Kotlińska JH, Filip M. 5-HT(2C) Receptor Stimulation in Obesity Treatment: Orthosteric Agonists vs. Allosteric Modulators Nutrients. 2023 Mar 17;15(6):1449._x000D_ 3: He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior Nat Med. 2022 Dec;28(12):2537-2546._x000D_ 4: Dunlop J, Watts SW, Barrett JE, Coupet J, Harrison B, Mazandarani H, Nawoschik S, Pangalos MN, Ramamoorthy S, Schechter L, Smith D, Stack G, Zhang J, Zhang G, Rosenzweig-Lipson S. Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist J Pharmacol Exp Ther. 2011 Jun;337(3):673-80._x000D_ 5: Kozell LB, Eshleman AJ, Swanson TL, Bloom SH, Wolfrum KM, Schmachtenberg JL, Olson RJ, Janowsky A, Abbas AI. Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)(2A) Receptor (5-HT(2A)R), 5-HT(2C)R, 5-HT(1A)R, and Serotonin Transporter J Pharmacol Exp Ther. 2023 Apr;385(1):62-75._x000D_ 6: Canal CE, Murnane KS. The serotonin 5-HT(2C) receptor and the non-addictive nature of classic hallucinogens J Psychopharmacol. 2017 Jan;31(1):127-143._x000D_ 7: Erkizia-Santamaría I, Alles-Pascual R, Horrillo I, Meana JJ, Ortega JE. Serotonin 5-HT(2A), 5-HT(2c) and 5-HT(1A) receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response Biomed Pharmacother. 2022 Oct;154:113612._x000D_ 8: Palacios JM, Pazos A, Hoyer D. A short history of the 5-HT(2C) receptor: from the choroid plexus to depression, obesity and addiction treatment Psychopharmacology (Berl). 2017 May;234(9-10):1395-1418._x000D_ 9: Leysen JE. 5-HT2 receptors Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):11-26._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/15113845">10: Schlag BD, Lou Z, Fennell M, Dunlop J. Ligand dependency of 5-hydroxytryptamine 2C receptor internalization J Pharmacol Exp Ther. 2004 Sep;310(3):865-70. </a>_x000D_ _x000D_ <strong>Products Related to Human 5-Hydroxytryptamine 2C Receptor can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>