Cinchonidine
Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].
Product Specifications
CAS Number
[485-71-2]
Product Name Alternative
α-Quinidine
UNSPSC
12352005
Hazard Statement
H302, H317, H361, H373
Target
Parasite; Serotonin Transporter
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Cinchonidine.html
Purity
99.62
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C=C[C@H]1C[N@](CC[C@H]1C2)[C@]2([H])[C@H](O)C3=CC=NC4=CC=CC=C34
Molecular Formula
C19H22N2O
Molecular Weight
294.40
Precautions
H302, H317, H361, H373
References & Citations
[1]Beckman ML, et al. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochem Int. 2014 Jul;73:98-106.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
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