DPCPX

DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].

Product Specifications

CAS Number

[102146-07-6]

Product Name Alternative

PD 116948

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dpcpx.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(N1CCC)N(CCC)C2=C(N=C(C3CCCC3)N2)C1=O

Molecular Formula

C16H24N4O2

Molecular Weight

304.39

Precautions

H302, H315, H319, H335

References & Citations

[1]S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40 (6) :555-61.|[2]R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335 (1) :59-63.|[3]POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97 (Suppl) : 496P–535P.