DPCPX
DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].
Product Specifications
CAS Number
102146-07-6
Product Name Alternative
PD 116948
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dpcpx.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(N1CCC)N(CCC)C2=C(N=C(C3CCCC3)N2)C1=O
Molecular Formula
C16H24N4O2
Molecular Weight
304.39
Precautions
H302, H315, H319, H335
References & Citations
[1]S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40 (6) :555-61.|[2]R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335 (1) :59-63.|[3]POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97 (Suppl) : 496P–535P.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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