GSK 1562590 (hydrochloride)

GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT[1].

Product Specifications

CAS Number

[1003878-07-6]

UNSPSC

12352005

Target

Urotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gsk-1562590-hydrochloride.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N([C@H](C1=CC=C(C2=CC=CC(C(N)=O)=C2)C=C1)CN3CCCC3)C)CN4C(COC5=CC(Cl)=C(Cl)C=C45)=O.Cl

Molecular Formula

C30H31Cl3N4O4

Molecular Weight

617.95

References & Citations

[1]Behm DJ, et, al. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. Br J Pharmacol. 2010 Sep;161 (1) :207-28.