Bictegravir-d4
Bictegravir-d4 is a deuterium of Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM[1].
Product Specifications
Product Name Alternative
GS-9883-d4
UNSPSC
12352005
Target
HIV; HIV Integrase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O=C(NC([2H])(C1=C(C([2H])=C(C([2H])=C1F)F)F)[2H])C2=CN(C[C@]3(O[C@@]4([H])C[C@@]([H])(N3C5=O)CC4)[H])C5=C(C2=O)O
Molecular Formula
C21H14D4F3N3O5
Molecular Weight
453.40
References & Citations
[1]Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60 (12) :7086-7097.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 4
Frequently Asked Questions
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