Sp-8-Br-cAMPS (sodium)
Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve[1][2].
Product Specifications
CAS Number
1573115-90-8
UNSPSC
12352005
Target
PKA
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sp-8-br-camps-sodium.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S[Na])=O)O3
Molecular Formula
C10H10BrN5NaO5PS
Molecular Weight
446.15
References & Citations
[1]Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83 (2) :150-9.|[2]Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169 (2) :802-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKA
Frequently Asked Questions
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